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Leucascandrolide A (I), a polyoxygenated marine macrolide of a new genus (Scheme I), was isolated in 1996 by Pietra and co-workers from the calcareous sponge Leucascandra caveolata. Despite intensive efforts, subsequent expeditions failed to provide additional quantities of I.doi:10.3929/ethz-a-004537989 fatcat:yljeab2ckzh57d6bfodbpotpp4