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Induction of High Affinity Glutamate Transport Activity by Amino Acid Deprivation in Renal Epithelial Cells Does Not Involve an Increase in the Amount of Transporter Protein
Journal of Biological Chemistry
In renal epithelial cells amino acid deprivation induces an increase in L-Asp transport with a doubling of the V max and no change in K m (4.5 M) in a cycloheximide-sensitive process. The induction of sodium-dependent L-aspartate transport was inhibited by single amino acids that are metabolized to produce glutamate but not by those that do not produce glutamate. The transaminase inhibitor aminooxyacetate in glutamine-free medium caused a decrease in cell glutamate content and an induction ofdoi:10.1074/jbc.271.21.12159 pmid:8647808 fatcat:wwf3ezzxcre7jhmcnkuzjka4ja