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COPD exacerbations occur in almost all patients, and half of patients in the Russian Federation (52%) have two or more exacerbations per year or require urgent admission to hospital. COPD exacerbations come from increased acute inflammation in the respiratory tract of a patient under the influence of many factors. Modern pharmacotherapy provides the physician with several options in reducing the number of exacerbations. This review provides evidence about the maximum reduction in exacerbationdoi:10.21518/2079-701x-2018-15-8-17 fatcat:mcfdht7oenhpbaa6f2neutg5hi