Hypercoagulopathy with Piperacillin Administration in Osteomyelitis

Hiroaki MIYAZAKI, Shingo YANAGITANI, Takayuki MATSUMOTO, Katsunori YOSHIDA, Yasuo AMOH, Toshihiko WATANABE, Yoshitugu KUBOTA, Kyoichi INOUE
2000 Internal medicine (Tokyo. 1992)  
A 51-year-old man with osteomyelitis developed acute renal failure and superior mesenteric venous (SMV)thrombosis after piperacillin (PIPC) treatment. Coagulation profile disclosed disseminated intravascular coagulation (DIC). The serum levels of IgE and eosinophil cationic protein showed significant increases, while a lymphocyte stimulation test with PIPC also demonstrated an extremely high index. These observations suggest that hypersensitivity to PIPC might play a role in the pathogenesis of
more » ... acute renal failure and SMVthrombosis due to hypercoagulopathy. Withdrawal of PIPC and anticoagulation therapy resulted in clinical improvementand normalization of the affected laboratory data. This is the first report to describe PIPCinduced hypercoagulopathy.
doi:10.2169/internalmedicine.39.424 fatcat:mchpidwr4vfxhnbke5cphnilly