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Hypercoagulopathy with Piperacillin Administration in Osteomyelitis
Internal medicine (Tokyo. 1992)
A 51-year-old man with osteomyelitis developed acute renal failure and superior mesenteric venous (SMV)thrombosis after piperacillin (PIPC) treatment. Coagulation profile disclosed disseminated intravascular coagulation (DIC). The serum levels of IgE and eosinophil cationic protein showed significant increases, while a lymphocyte stimulation test with PIPC also demonstrated an extremely high index. These observations suggest that hypersensitivity to PIPC might play a role in the pathogenesis ofdoi:10.2169/internalmedicine.39.424 fatcat:mchpidwr4vfxhnbke5cphnilly