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RAGA: RNA sequence alignment by genetic algorithm
1997
Nucleic Acids Research
We describe a new approach for accurately aligning two homologous RNA sequences when the secondary structure of one of them is known. To do so we developed two software packages, called RAGA and PRAGA, which use a genetic algorithm approach to optimize the alignments. RAGA is mainly an extension of SAGA, an earlier package for multiple protein sequence alignment. In PRAGA several genetic algorithms run in parallel and exchange individual solutions. This method allows us to optimize an objective
doi:10.1093/nar/25.22.4570
pmid:9358168
pmcid:PMC147093
fatcat:yze3xxoeajh27f2wz2gsnl5z6i