Role of Cytochrome P450 Systems in Substance of Abuse Mediated HIV-1 Pathogenesis and NeuroAIDS
Journal of Drug Metabolism & Toxicology
The impact of HIV-1 pathogenesis, substance of abuse, and AIDS development and progression in neurons (neuroAIDS) on neurodegeneration has been discussed in the recent edition of "The neurology of AIDS" . This book also covers the perspectives of HIV-infected patients who suffer from neurodegeneration. Their perspectives are intriguing and an eye-opener for the researchers in the field of substance of abuse and neuroAIDS. Further, the book highlights several unresolved issues that need to be
... ues that need to be addressed in order to rescue/decrease AIDS and neuroAIDS development, especially in the populations who regularly consume substances of abuse. Thus, there is a critical need to investigate alternate pathway that is responsible for neuroAIDS associated neurodegeneration among HIV-infected substance of abusers. This would help discover novel interventions as well as drug dose adjustments for these individuals. This editorial article highlights: 1) Problems associated with HIV-1 and substance of abuse; 2) Possible role of alternate cytochrome P450 pathway in substance of abuse associated HIV-1 pathogenesis: Brief review of the literatures; 3) Proposed alternate cytochrome P450 pathway in substance of abuse associated HIV-1 pathogenesis: Author's perspectives; 4) Conclusion.