A Comprehensive Review of Thrombogenic Mechanisms in APS~!2009-10-13~!2009-10-19~!2010-03-11~!

Renan Aguilar-Valenzuela, Laura Aline Martinez-Martinez, Silvia S. Pierangeli
2010 The Open Autoimmunity Journal  
The antiphospholipid syndrome (APS) is an acquired thombophilia, which is characterized by one or more thrombotic episodes and obstetric complications in the presence of antiphospholipid (aPL) antibodies (Abs). aPL Abs are detected by laboratory tests such as lupus anticoagulant (LA), anticardiolipin (aCL) and anti-2 -glycoprotein I ( 2 GPI) Abs. This article reviews the most current pathophysiological aspects of APS with emphasis in thrombotic and proinflammatory mechanisms mediated by aPL
more » ... mediated by aPL antibodies.
doi:10.2174/1876894601002020058 fatcat:zj4pyg4oirebjibeikb7xefhse