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T cell activation: in vivo veritas
Immunology and Cell Biology
Phenotypic changes in CD4 + T cells undergoing antigen-dependent activation were compared in vivo and in vitro . The most obvious difference was in expression of CD25, the alpha chain of the high affinity receptor for IL-2. High level expression of CD25 in vivo is restricted to a small fraction of the cells at the leading edge of the cell division profile, whereas all activated cells express high levels of CD25 in cultures responding to antigen. Because IL-2 is known to upregulate expression ofdoi:10.1111/j.0818-9641.2004.01243.x pmid:15186257 fatcat:bm3hi7cb6zfgzicw4l7sxnkf44