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This work aimed to study the pathological changes induced in theurinary organs after infection with K.pneumoniae. Two laboratory femaleanimal species ,white rat&guinea pig ,were infected by tworoutes,ascending (first group) and direct(intra renal-second group).The infection was examined in different periods through the bacterialculture of urine & kidney samples as well as the pathological changes(grossµscopic) were examined after post mortum.The resultes of both groups showed a positivedoi:10.30539/iraqijvm.v32i2.740 fatcat:lvoiotisxje2fhdtgaxmztlvpm