Comparative toxicity of strontium-90 and radium-226 in beagle dogs. Report of second year, December 16, 1990--December 15, 1991 [report]

O.G. Raabe, M.R. Culbertson, R.G. White, W.L. Spangler, G.R. Cain, N.J. Parks, S.J. Samuels
1991 unpublished
EXECUTIVE SUMMARY We are completing a 3G-year study of the biological effects of 9°Sr and 226Rain the beagle in orderto predict the possible long-term hazards to people from chronic exposure to low levels of irradiation. Animals received either radionuclide by several means of administration: (a) continual ingestion of 9°Sr, (b) a single intravenous injection of 9°Sr, or (c) a series of eight intravenous injections of 226Ra. Although administration of 9°Sr and 226Ra ended at 540 days of age,
more » ... 540 days of age, the animals continued to receive chronic, low-level radiation doses from these bone-seeking radionuclides throughout fife. This project is the largest single cohort study in beagles of internally deposited radionuclides. It is unique in use of the ingestion route for 9°Sr and in exposures that began before birth and continued throughout development to adulthood with uniform labeling of the skeletons with 9°Sr. The last of the dogs died in 1986 at age 18.5 years, but we are continuing to investigate the significance of these long-term exposures given at low dose rates with regard to cancer production, physiologic well-being, and shortening of life through the detailed records that were kept and by study of preserved materials. All the data have been successfully accumulated and entered into a main-frame computer data base management system. Current work is exclusively directed at preparing research papers summarizing the results and the associated biostatistical and survival analyses.
doi:10.2172/10122161 fatcat:qjvzbqtgtvgrvdowgefnfwskjy