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Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells
[article]
2022
bioRxiv
pre-print
AbstractCell division fidelity is crucial for stem cell propagation and the maintenance of pluripotency. Centrosomes, which organize the mitotic spindle microtubules to ensure proper bipolar cell division, have a core of a pair of centrioles that duplicate once per cell cycle. At the onset of centriole biogenesis, SAS-6 forms a cartwheel structure, which is the precursor for the forming procentrioles. SAS-6 is essential for centriole formation in human cell lines and other organisms. However,
doi:10.1101/2022.08.11.503634
fatcat:weljtfnb7zcqld5j2ankbhydpq