Chronic lymphocytic leukemia

Talha Munir
2015 Hematology  
Karyotype complexity and VH gene status in B-cell chronic lymphocytic leukemia B-cell chronic lymphocytic leukemia-related genomic changes were analyzed by karyotyping, fluorescence in situ hybridization, and VH gene sequencing in a prospective clinical evaluation. The VH mutational status correlated with high-risk cytogenetic aberrations while no such relation could be demonstrated for specific VH gene usage (V3-21 and V1-69) . Complex karyotypes were highly indicative of disease progression.
more » ... sease progression. Letters to the Editor haematologica/the hematology journal | 2006; 91(10) | 1431 | © F e r r a t a S t o r t i F o u n d a t i o n
doi:10.1179/1024533215z.000000000356 pmid:25906256 fatcat:ekd2x2tshjhondgqzx7qwv2mxa