Long non-coding RNAs regulate drug resistance in cancer

Kaisheng Liu, Lin Gao, Xiaoshi Ma, Juan-Juan Huang, Juan Chen, Leli Zeng, Charles R. Ashby, Chang Zou, Zhe-Sheng Chen
2020 Molecular Cancer  
Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various mechanisms. Over the last decade, it has been reported that 1ong noncoding RNAs (lncRNAs) can mediate carcinogenesis and drug resistance/sensitivity in cancer cells. This article reviews, in detail, recent studies regarding the roles of lncRNAs in mediating drug resistance.
doi:10.1186/s12943-020-01162-0 pmid:32164712 fatcat:3tvgrj7rsrg2vnmho43evz6kyy