Banana Peel Extract as Adjuvant Therapy for Periodontitis: Histometrical and Morphometrical Analysis in Rattus norvegicus

Suryono, Vincensia Maria Karina, Osa Amila Hafiyyah, Delia Nigrahaning Rasti, Citra Ayu Widowati, Ainul Khusna
2018 International Journal of Medicine and Pharmacy  
Purpose : To examine the effectivity of Banana (Musa paradisiaca L.) peel extract gel as adjuvant therapy for periodontitis. Sample: this experiment used 57 rats which divided into three groups; positive control group (received hyaluronic acid gel), treatment group (received banana peel extract) and negative control group (received base gel without active ingredient). Method: Aggregatibacteractinomycetemcommitanssus pension was injected on palatal surface of upper second molar of rats to induce
more » ... r of rats to induce periodontitis. The rats then treated with hyaluronic acid gel, banana peel extract gel and base gel based on its group on upper molar teeth twice a day. Histological evaluation was performed to evaluate treatment effectivity after 3, 5, 7, 14, and 28 days using Haematoxylin Eosin and Mallory Trichrome staining. Result: 10% banana peel extract increased angiogenesis, alveolar bone height and collagen density. Angiogenesis on treatment group was statistically different (p<0,05) from other groups, with means value of angiogenesis 10,89. Alveolar bone height measurement using morphometric method showed 379µm whereas histometric alveolar bone height showed 163,5µm. Collagen density also observed higher with the other group (51,24%). Conclusion: Banana (Musa paradisiaca L.) peel extract gel can be used as adjuvant therapy candidate for periodontitis.
doi:10.15640/ijmp.v6n2a3 fatcat:ewd2hwgok5dsfhgter5r3t55ri