Antibacterial Activity of Different Extracts of Centaurea cyanus (L.) Growing Wild in Kosovo

Arben Haziri, Fatmir Faiku, Ibrahim Rudhani, Ibrahim Mehmeti, Diedona Motori
2017 Oriental Journal of Chemistry  
In this study the antibacterial efficiency of different organic extracts from Centaurea cyanus (L.) growing wild in Kosovo were examined. Methanol, ethyl acetate, acetone, diethyl ether, water and chloroform extracts were tested against three gram positive bacteria Staphylococcus aureus (food isolate), Staphylococus aureus (clinical isolate), Listeria monocytogenes (clinical isolate) one gram negative bacteria Escherichia coli (clinical isolate). The antibacterial activity was determined by
more » ... s determined by using agar disc diffusion method. The inhibition zone of extracts was compared to that of penicillin G as standard. Based on the results, the most intense activity was shown by the plant's extracts with water and ethyl acetate. The ethyl acetate extract showed activity in all of the concentrations 1, 3 and 5 mg/mL towards S. aureus (food isolate), E. coli (clinical isolate), S. aureus (clinical isolate) and L. Monocytogenes (clinical isolate). Ethyl acetate extract of the plant with concentration 5 mg/ mL showed a stronger antibacterial activity towards bacteria E. coli with inhibition zone of 12 mm. Aqueous extract of the plant with concentration 5 mg/ mL showed a stronger antibacterial activity against bacteria E. coli with inhibition zone of 12 mm. Also aqueous extracts of the C. cyanus (L.) showed a stronger antibacterial activity as penicillin G against bacteria S.s aureus (clinical isolate). From the obtained results, the most antibacterial activity has water and ethyl acetate extracts. The antibacterial activity of the C. cyanus (L.) was due to the presence of various secondary metabolites such as phenols and flavonoids. Hence, this plant can be used to discover bioactive natural products that may serve as leads in the development of new pharmaceuticals.
doi:10.13005/ojc/330406 fatcat:xuprjcbmybawbl6uek4ufro3s4