STUDY ON NONALCOHOLIC STEATOHEPATITIS (NASH) IN PATIENTS OF OBESE, TYPE 2 DIABETES MELLITUS
English

Uma Shankar Mishra, Jogendra Patra
2018 Journal of Evidence Based Medicine and Healthcare  
BACKGROUND Nonalcoholic steatohepatitis (NASH) represents only a part of a wide spectrum of non-alcoholic fatty liver disease (NAFLD) and its prevalence is only 2-3% in the general population. Diabetes mellitus increases the risk for severe necroinflammation. The diagnosis rests on the hallmark histological features. Liver biopsy is essential for positive diagnosis and prognostication of NASH. The aim of this study was to evaluate the correlation between NASH and risk factor like diabetes, BMI
more » ... like diabetes, BMI and other risk factors. RESULTS Twenty out of thirty-six patients had diabetes in our study i.e. 55.6% were diabetes. 22 out of 36 patients i.e. 61.1% had BMI >28 kg/m 2 . the mean waist circumference in our study was 93.13 Cm. 15 out of 24 female patients i.e. 62.5% females had WC>88 cm and 8 out of 12 male patients i.e. 66.7% males had WC >102 cm., 20 out of 36 patients i.e. 55.6% patients fulfilled at least 3 out of 5 criteria and therefore had insulin resistance syndrome or metabolic syndrome. CONCLUSION Patients with NASH are typically asymptomatic unless cirrhosis develops. 97.22% patients were dyslipidaemics. NASH may be considered an additional features of insulin resistance & metabolic syndrome. Age, gender, waist circumference, BMI, ALT, AST: ALT ratio, serum triglyceride levels, HTN & BAAT score are independent predictors of NASH. KEYWORDS NASH Nonalcoholic Steatohepatitis AST Transaminase, Diabetes Mellitus HDL High Density Lipid LDL Low Density lipid TG Triglyceride, NAFLD-Nonalcoholic Fatty Liver Disease. HOW TO CITE THIS ARTICLE: Mishra US, Patra J. Study on nonalcoholic steatohepatitis (NASH) in patients of obese, type 2 diabetes mellitus.
doi:10.18410/jebmh/2018/132 fatcat:nz6ge3qtzzatzif3fd6ouj22we