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Three-dimensional (3D) structure is now known for a large fraction of all protein families. Thus, it has become rather likely that one will find a homolog with known 3D structure when searching a sequence database with an arbitrary query sequence. Depending on the extent of similarity, such neighbor relationships may allow one to infer biological function and to identify functional sites such as binding motifs or catalytic centers. Entrez's 3D-structure database, the Molecular Modeling Databasedoi:10.1093/nar/gkl952 pmid:17135201 pmcid:PMC1751549 fatcat:ogsj353nmrhddfzlql2fpwrpay