Seishin-Renshi-In (TJ-111) (Qing-Xin-Lian-Zi-Yin) was administered to seven patients with non-insulin-dependent diabetes mellitus (NIDDM). Five years treatment with TJ-111 was three male patients, three years was one female patient, and two years was two female patients. All of them received 7.5g of TJ-111 per day, 30 minutes before every meal. Body weight and HbAI were examined and recorded at intervals during the whole period of administration. Patients whose HbAI was increased by more than

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... transiently showed the increases of body weight. It was proved that it is important to keep the calorie intake at an appropriate level and to exercise every day for adjusting body weight even in the treatment of Kampo medicine. The patients who decreased body weight by daily training were considered to be "Kyo-Sho", and it is suggested to administer Seishin-Renshi-In for the treatment of NIDDM in the concept of Kampo medicine. No side effects were recognized in any cases of treatment with Seishin-Renshi-In.