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During the past decades the components involved in cellular signal transduction from membrane receptors to gene activation in the nucleus have been studied in detail. Based on the qualitative biochemical knowledge, signalling pathways are drawn as static graphical schemes. However, the dynamics and control of information processing through signalling cascades is not understood. Here we show that based on time resolved measurements it is possible to quantitatively model the nonlinear dynamics ofdoi:10.1142/s0218127404010461 fatcat:qi36vlcsazbkdcvhgq4y7zrbae