Association of PAH-DNA Adducts in Peripheral White Blood Cells with Dietary Exposure to Polyaromatic Hydrocarbons

Nathaniel Rothman, Miriam C. Poirier, Robert A. Haas, Adolfo Correa-Villasenor, Patrick Ford, John A. Hansen, Tara O'Toole, Paul T. Strickland
1993 Environmental Health Perspectives  
Previous investigations suggest that dietary soumres of polycyclic aromatic hydrocarbons (PAH1s) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, wmeasred PAH-DNA adducts by enzymelinked immunosorbent assay in WBCs obtained from 47 California wildland (forest) firefighters at two time points (early and late) duringan active forest fire season. PAH-DNA adduct levels were not associated with recent firefighting activity, but were positively
more » ... ated with frequency ofcharbroiled food consumption in the previous 2 weeks. In addition, adduct levels declined with time since last ingestion ofcharbroiled food. These studies indicate that recent consumption of charbroiled food contributes to the PAH-DNA adduct load in peripheral WBCs.
doi:10.2307/3431497 fatcat:styfv4s7enfmldcbchnnnuwkwe