The existence of stable links and knots is demonstrated in three-dimensional, bistable, chemical media. The reaction-diffusion medium segregates into regions of high and low concentration separated by sharp interfaces. The interfaces repel at short distances so that domains with various topologies are possible depending on the initial conditions and system parameters. Front instabilities can give rise to knotted labyrinthine patterns. A lattice-gas model whose mean-field limit is the

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... gumo equation is described and implemented to carry out the simulations.