e441 distributed all over the world, and the infection is prevalent in both developing and developed countries. Although 5-nitroimidazole compounds have been used for Giardiasis treatment for several years, the increasing number of reports of refractory cases and side effects of some drugs resulted in establishment of more investigation for new compounds.The aim of present study was to compare the efficacy of praziquantel and Mebendazole, given as a single -dose, with Metronidazole, given 5-7

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... ys, in the treatment of Giardiasis. Methods: In a randomized clinical trial, 90 subjects, each proven to be infected with G.L by the microscopically examination of fecal sample, were randomly allocated to 3 groups, Group 1 was given praziquantel as a single -dose, Groups 2 mebendazole as a singledose and Group 3 metronidazole for 7 days, parasitological cure was documented when there was 3 times negative stool examination for G.L at 7 -10 days after therapy Results: Seventeen of 30 individuals (56.6%) treated with praziquantel and 15 of 30 individuals (50%) treated with mebendazole and 28 of 30 individuals (93%) treated with metronidazole were cured. Cure rate between praziquantel and mebendazole wasn't significantly different) P>0.05), but between these (praziqunted, mebendazole) and metronidazole, the difference was significant (P < 0.05). No side effects of these drugs were observed. Conclusion: Metronidazole as a standard dose is more effective in the treatment of Giardiasis.