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Relocalization of cell adhesion molecules during neoplastic transformation of human fibroblasts
2011
International Journal of Oncology
Studying neoplastic transformation of telomerase immortalized human fibroblasts (cen3tel), we found that the transition from normal to tumorigenic cells was associated with the loss of growth contact inhibition, the acquisition of an epithelial-like morphology and a change in actin organization, from stress fibers to cortical bundles. We show here that these variations were paralleled by an increase in N-cadherin expression and relocalization of different adhesion molecules, such as N-cadherin,
doi:10.3892/ijo.2011.1119
pmid:21750862
fatcat:of2oflaw2vhi3fshrsm7yml4mq