SYNTHESIS, CHARACTERIZATION AND CRYSTAL STRUCTURE OF 3'-[(4-FLUOROPHENYL)CARBONYL]-5'-(HYDROXYMETHYL)-4'-PHENYL SPIRO[INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE

Ratika Sharma, M. Sapnakumari, B. Narayana, B. K. Sarojini, Vivek K. Gupta, Rajni Kant
2013
The title compound 3'-[(4-fluorophenyl)carbonyl]-5'-(hydroxymethyl)-4'-phenyl spiro[indole-3,2'-pyrrolidin]-2(1H)-one is synthesized by the straightforward multicomponent reaction of 1-(4-fluorophenyl)-3-phenylprop-2-en-1-one, isatin and serine, and is crystallises in monoclinic space group C2/c.The molecule is essentially planar except one of the pyrrolidin ring which adopts normal envelope conformation. The supermoleular assembly is consolidated by ᴨ-ᴨ interactions [centroid- centroid
more » ... = 3.7983(18)]. The crystal structure is stabilized by one C-H...O intra-hydrogen bond, two N-H...O and one O-H...N inter-hydrogen bonds, and these interactions links the molecules into chain extending along the b-axis.
doi:10.17628/ecb.2014.3.183-186 fatcat:3fmp7m7xvbccffg7ygobjbi4dq