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HIV-1 Protease and Reverse Transcriptase Control the Architecture of Their Nucleocapsid Partner
2007
PLoS ONE
The HIV-1 nucleocapsid is formed during protease (PR)-directed viral maturation, and is transformed into pre-integration complexes following reverse transcription in the cytoplasm of the infected cell. Here, we report a detailed transmission electron microscopy analysis of the impact of HIV-1 PR and reverse transcriptase (RT) on nucleocapsid plasticity, using in vitro reconstitutions. After binding to nucleic acids, NCp15, a proteolytic intermediate of nucleocapsid protein (NC), was processed
doi:10.1371/journal.pone.0000669
pmid:17712401
pmcid:PMC1940317
fatcat:x2g4vwyhabcw3mg46b2m7qfqba