By using continuation theorem of coincidence degree theory, sufficient conditions of the existence of positive periodic solutions are obtained for a generalized predator-prey system with diffusion and delays. In this paper, we construct a V-function to make the prior estimation for periodic solutions, which makes the discussion more concise. Moreover, to compute the mapping's topological degree, a polynomial function matrix is constructed straightforwardly as a homotopic mapping for the

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... zed one, which improves the methods of computation on topological degree for a generalized mapping.