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The abnormalities in human metabolism have been implicated in the progression of several complex human diseases, including certain cancers. Hence, deciphering the underlying molecular mechanisms associated with metabolic reprogramming in a disease state can greatly assist in elucidating the disease aetiology. An invaluable tool for establishing connections between global metabolic reprogramming and disease development is the genome-scale metabolic model (GEM). Here, we review recent work on thedoi:10.1093/bib/bbaa002 pmid:32201876 pmcid:PMC7986590 fatcat:wis2yufpenb3nbjiludbgh6kdu