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Axin-mediated regulation of lifespan and muscle health in C. elegans involves AMPK-FOXO signaling
Aging is a significant risk factor for several diseases. Studies have uncovered multiple signaling pathways that modulate the process of aging including the Insulin/IGF-1 signaling (IIS). In C. elegans the key regulator of IIS is DAF-16/FOXO whose activity is regulated by phosphorylation. A major kinase involved in DAF-16-mediated lifespan extension is the AMPK catalytic subunit homolog, AAK-2. In this study, we demonstrate a novel role of PRY-1/Axin in AAK-2 activation to regulate DAF-16doi:10.1101/2020.04.22.055962 fatcat:7yz2ttw2f5cyxm3ntlkixcgr2i