Profil Pasien Sakit Kritis dengan Penyakit Jamur Invasif Dini

Gurmeet Singh, Ceva Pitoyo, Dita Aditianingsih, Cleopas Rumende
unpublished
The incidence of Invasive Fungal Disease (IFD) is increasing worldwide in the past 2 to 3 decades. Critically ill patients in Intensive Care Units (ICU) are more vulnerable to fungal infection. Early detection and treatment are important to decrease morbidity and mortality in critically ill patients. Objective: To profile critically ill patient associated with early invasive fungal disease. Method: Prospective cohort study was conducted on critically ill patients at Cipto Mangunkusumo Hospital
more » ... gunkusumo Hospital within March 2015-September 2015 period. Total number of subject (74) in this study was drawn based on one of the risk factor (HIV). Specimens were collected on day 5 to 7 of hospitalization. Results: A total of 206 patients were enrolled in this study. Among 74 subjects with IFD, majority were males (52.7%), mean age was 58 years (range 18-79), mean Leon's Scores was 3 (score range 2-5), majority group was non-surgical/ non-trauma patient (72.9%), and mean fungal isolation was positive on the 5 th day. The highest number of isolated fungal specimen found in this study was Candida sp (92.2%). Urine culture yields the highest fungal isolates (70.1%). Mortality rate in this study was 50%. Conclusion: Incidence of early invasive fungal disease mostly found in critically ill patients with high mortality rate.
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