COVID-19 patients have increased levels of membrane-associated and soluble CD48 [article]

Hadas Pahima, Ilan Zaffran, Eli Ben-Chetrit, Amir Jarjoui, Pratibha Gaur, Maria Laura Manca, Dana Reichmann, Efrat Orenbuch-Harroch, Ilaria Puxeddu, Carl Zinner, Alexandar Tzankov, Francesca Levi-Schaffer
2022 bioRxiv   pre-print
COVID-19 is a respiratory-centered systemic disorder caused by SARS-CoV-2. The disease can progress into a severe form causing acute lung injury. CD48 is a co-signaling receptor, existing as both membrane-bound and soluble forms reported to be dysregulated in several inflammatory conditions. Therefore, we reasoned that CD48 could be deregulated in COVID-19 as well. Here we analyzed CD48 expression in autoptic sections and peripheral blood leukocytes and sera of COVID-19 patients by gene
more » ... on profiling (HTG autoimmune panel), immunohistochemistry, flow cytometry and ELISA. Lung tissue of COVID-19 patients showed increased CD48 mRNA expression and infiltration of CD48+ lymphocytes. In the peripheral blood, mCD48 was considerably increased on all evaluated cells, and additionally, sCD48 levels were significantly higher in COVID-19 patients independently of disease severity. Considering the alterations of mCD48 and sCD48, a specific role for CD48 in COVID-19 can be assumed, suggesting it as a potential target for therapy.
doi:10.1101/2022.03.18.484843 fatcat:ekdmukoyq5depffjncyu4i2wn4