X-Ray Studies on Phospholipid Bilayers. XIII. Interactions with Gentamicin

M. Suwalsky, J. Frías
1993 Zeitschrift für Naturforschung C - A Journal of Biosciences  
This study deals with the structural perturbations that the aminoglycoside antibiotic gentamicin (GENT) can produce to phospholipid bilayers. Two multibilayer systems, one built-up of dimyristoylphosphatidylcholine (DMPC) and the other of dimyristoylphosphatidylethanolamine (DMPE) were allowed to interact with GENT. The experiments were performed in both a hydrophobic and a hydrophilic medium below the phospholipid main transition tem­peratures. X-ray diffraction techniques were used to
more » ... e the extent of the perturbation induced by GENT. The maximum effect was attained when GENT interacted with DMPC in the hydrophobic medium. On the other hand, GENT in aqueous solutions was unable to per­turb in any significant extent the structure of the phospholipids under study.
doi:10.1515/znc-1993-7-817 fatcat:hncs74ruezbehgsmkifeerlpqa