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Regulation of antibody responses against self and foreign antigens by Tfr cells: implications for vaccine development
Oxford Open Immunology
The production of antibodies can constitute a powerful protective mechanism against infection, but antibodies can also participate in autoimmunity and allergic responses. Recent advances in the understanding of the regulation of germinal centres (GC), the sites where B cells acquire the ability to produce high-affinity antibodies, offered new prospects for the modulation of antibody production in autoimmunity and vaccination. The process of B cell affinity maturation and isotype switchingdoi:10.1093/oxfimm/iqab012 pmid:36845568 pmcid:PMC9914583 fatcat:5lihbazpkfh3lnfyzm3hpkmu7i