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MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain
Genes & Development
The regulation of MHC class II gene expression controls T-cell activation and, hence, the immune response. Among the nuclear factors observed to bind to conserved DNA sequences in human leukocyte antigen (HLA) class II gene promoters, RFX is of special interest: Its binding is defective in congenital HLA class II deficiency, a disease of class II gene regulation. The cloning of an RFX cDNA has allowed us to show by transfection of a plasmid directing the synthesis of antisense RFX RNA that RFXdoi:10.1101/gad.4.9.1528 pmid:2253877 fatcat:a467ichzfnhsnjqr6u4zeairsy