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Uneven distribution of cobamide biosynthesis and dependence in bacteria predicted by comparative genomics
[article]
2018
bioRxiv
pre-print
The vitamin B12 family of cofactors known as cobamides are essential for a variety of microbial metabolisms. We used comparative genomics of 11,000 bacterial species to analyze the extent and distribution of cobamide production and use across bacteria. We find that 86% of bacteria in this data set have at least one of 15 cobamide-dependent enzyme families, yet only 37% are predicted to synthesize cobamides de novo. The distribution of cobamide biosynthesis varies at the phylum level, with 57%
doi:10.1101/342006
fatcat:6ag7oxqr5ngarl7bwxivtc25ua