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Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging
2019
Molecules and Cells
Tracking the fate of individual cells and their progeny through lineage tracing has been widely used to investigate various biological processes including embryonic development, homeostatic tissue turnover, and stem cell function in regeneration and disease. Conventional lineage tracing involves the marking of cells either with dyes or nucleoside analogues or genetic marking with fluorescent and/or colorimetric protein reporters. Both are imaging-based approaches that have played a crucial role
doi:10.14348/molcells.2019.0006
pmid:30764600
pmcid:PMC6399003
fatcat:x5wcwpbacnhw7bpvsp55xra6rq