Induced abortion and risk of subsequent miscarriage

Yuelian Sun, Yan Che, Ersheng Gao, Jørn Olsen, Weijin Zhou
2003 International Journal of Epidemiology  
Induced abortion is used worldwide to terminate unwanted pregnancies. In China, vacuum aspiration is a major technique to end first-trimester pregnancies. This technique is believed to be relatively safe-little trauma is caused to the cervix and uterus. Such a conclusion is supported by a number of studies, 1-3 but is surrounded by much controversy. For instance, a recent largescale Danish study showed an increased risk of miscarriage following prior induced abortion among women who got
more » ... men who got pregnant within 3 months after the abortion. 4 Since 50 million abortions may occur worldwide annually, 5 even a small adverse effect may be of public health importance. In this paper, we used the data from a cohort study to re-evaluate the relationship between miscarriage and prior induced abortion. Background To evaluate the impact of surgically induced first-trimester abortion on the risk of miscarriage in a subsequent pregnancy. Methods The study is a pregnancy cohort study. It was conducted among 15 general hospitals or maternity and infant health institutes in Shanghai, China from November 1993 to March 1998. The abortion cohort consisted of pregnant women whose previous pregnancies were terminated by vacuum aspiration (98%). The reference cohort consisted of primigravidae. Subjects were recruited at 35-63 days of gestational age. A total of 2953 pregnant women were enrolled; 1502 in the abortion cohort, 1451 in the reference cohort. Results There were only 62 women lost to follow-up. The remaining 2891 women had 2732 live births, and 137 miscarriages. About 5.5% of pregnancies in the abortion cohort were miscarried and 4.0% in the reference cohort. Once potential confounders were controlled for by logistic regression, odds ratio (OR) of miscarriage between the abortion cohort and the reference cohort was 1.55 (95% CI: 1.08-2.23). The adjusted OR were 2.44 (95% CI: 1.16-5.15) among women who were recruited within 49 days of gestational age, and 1.72 (95% CI: 1.09-2.72) for the first-trimester miscarriage. Conclusions Induced abortion by vacuum aspiration is associated with an increased risk of first-trimester miscarriage in the subsequent pregnancy.
doi:10.1093/ije/dyg093 pmid:12777435 fatcat:3kesjdbsgzfq5dc7gv44g44pwq