Early evolution of resistance to oxidative stress after sub-arachnoid hemorrhages: A cohort study of 50 patients

Patrice Thierry, Bertrand Rozec, Romain Bourcier, Hubert Desal, Yvonnick Blanloeil
2018 Clinical Case Reports and Reviews  
and purpose: The role of Reactive Oxygen Species (ROS) is suspected during subarachnoid haemorrhage. We analysed the early changes in the resistance to ROS (RROS) as a function of the vital prognosis at Day 15 together with other prognostic markers. Methods: Fifty patients had been successively recruited and RROS has been measured using a new method involving the detection of ROS after a standardised singlet oxygen production at Day 1 (D1), 5 and 10 after SAH. Influence of RROS had been
more » ... OS had been considered as a predictive tool of death at day 15 together with WFNS and Glasgow scoring, C-reactive protein, Protein S100B (P S100B) as well as aneurism location or the occurrence of a vasospasm and patients' history. Results: Resistance to ROS at D1 was in 82% of cases greater than in healthy controls. In case of death a decrease of RROS was noted after D5 when it remained low but stable for others. It correlated with WFNS and Glasgow scoring. These changes correlated also with poor prognosis aneurisms locations and the occurrence of vasospasm. P S100B was an efficient initial marker of prognosis but RROS changes correlated better with survival along with survival time. Conclusion: Resistance to ROS is strongly modified after an SAH and seems to be a metabolic marker of prognosis after an SAH providing additional data to clinical scores or pathologic markers of damages to brain matter. It could be used in the future to monitor real time changes induced by prescribed anti-oxidative medications.
doi:10.15761/jaa.1000115 fatcat:k5gbmsbjwra6jluiryjdsbmlmy