INTEGRATOR: interactive graphical search of large protein interactomes over the Web

Aaron N Chang, Jason McDermott, Zachary Frazier, Michal Guerquin, Ram Samudrala
2006 BMC Bioinformatics  
The rapid growth of protein interactome data has elevated the necessity and importance of network analysis tools. However, unlike pure text data, network search spaces are of exponential complexity. This poses special challenges for storing, searching, and navigating this data efficiently. Moreover, development of effective web interfaces has been difficult. We present Integrator, a web-integrated graphical search tool for protein-protein interaction networks across 50+ genomes. Integrator
more » ... des single and multiple protein searches of the Bioverse database containing experimentally-derived and predicted protein-protein interactions. The interface provides animated local network views, rapid subgraph manipulation, and cross-referencing of functional annotations. Integrator is available at
doi:10.1186/1471-2105-7-146 pmid:16542421 pmcid:PMC1459205 fatcat:uaed6t2sunep7hlyd4jnyfpfai