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Factor XIII, Fibrin and Collagen
Thrombosis and Haemostasis Vth Congress
The significance of factor XIII (fibrin stabilizing factor) in hemostasis and wound healing is well known. The significance of fibrincrosslinking has, however, not been unequivocally demonstrated. As an additional hypothesis we postulated that factor XIII could bind fibrin to collagen by transamidination. To test this hypothesis:1) Normal plasma or F XIII deficient plasma, collagen or buffer, Ca++ and thrombin were incubated at 37°. The clots were washed and dissolved in SDS, urea anddoi:10.1055/s-0039-1689318 fatcat:r7dgqopj5bh7lbt6a6y4wkjus4