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In Escherichia coli, three isoforms of the essential translation initiation factor IF2 (IF2-1, IF2-2, and IF2-3) are generated from separate in-frame initiation codons in infB. The isoforms have earlier been suggested to act differentially in DNA replication restart. We report that in synthetic lethal situations associated with trapped Holliday junctions caused by deficiency of enzymes RuvAB or RuvC (that act in the post-synaptic step of homologous recombination [HR]), viability is restored indoi:10.1101/2021.06.16.448654 fatcat:nwpjfr5epve2pf6pq55zj7eiv4