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Almost all methods of detecting brain activation in fMRI data depend on prior knowledge of mental event timing. For example, the investigator may be required to stipulate the short time intervals during which mental activity occurs. In addition, the hemodynamic response to mental activity is often assumed to be linearly additive, and the shape of that response is frequently estimated or modeled. Analysis methods that do not make these assumptions still require prior knowledge of characteristicsdoi:10.1006/nimg.2000.0663 pmid:11133318 fatcat:qy54lg326bflneevxjthalo6ti