Evidence of Non Binary Synaptic Activity in Cortex

isabel delgado ruz, Simon R. Schultz, Paul T. Chadderton
2023 figshare.com  
Traditionally, a binary view of neuronal-brain activity has been adopted for analysis. This simplification is adequate in most situations for a general understanding of how computations and transformations are done. Through binary representation we have learned how information is transmitted in the brain and how stimuli is represented by population brain activity. However, increasing evidence shows that this view discards relevant information used by upstream neurons. In this paper we show
more » ... g evidence of non binary synaptic activity reflected on different aspects of the full waveforms: pre-synaptic waveform presents consistent variations which many times do not occur at the soma (recording channels with largest amplitude); shape of pre-synaptic waveform influences synaptic efficiency (number of induced post-synaptic spikes); post-synaptic waveform also shows variations visible on the spatio-temporal profile (which can occur at soma, dendrites or axons).
doi:10.6084/m9.figshare.12153522.v4 fatcat:qfdo7bnm3rhk5cjmvsh2ksoudu