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In this contribution we present a multiscale modeling approach to systematically explore the heterogeneity of biopolymer production in multicellular systems. The first step is a dynamic single cell model which is based on the hybrid cybernetic modeling approach to include cell internal regulation. The single cell model is used for nonlinear analysis and the occurrence of multiple steady states is discussed. The single cell model is then reduced by using the lumped hybrid cybernetic approach anddoi:10.3182/20120215-3-at-3016.00057 fatcat:krdrnsomr5cdjaf4pfuru7gi5e