Isolation and Synthesis of a Hemoregulatory Peptide

Walter R. Paukovits, Ole D. Laerum
1982 Zeitschrift für Naturforschung C - A Journal of Biosciences  
A peptide was isolated in pure form from human leukocytes which strongly inhibits the proliferation of immature meyloid cells in vitro (committed stem cells). Structural investigations yielded pGlu-Asp or Glu-Asp or Glu-Cys-Lys-OH as the probable sequence of this peptide. The Glu2,Asp3-analog, prepared synthetically, displayed similar activities and when applied in vivo showed effects on the hemopoietic system ranging from an inhibition of pluripotent and committed stem cells to variations in
more » ... e bone marrow proliferation and alterations in peripheral blood counts.
doi:10.1515/znc-1982-11-1236 fatcat:lmspz3j2nnhmrczmc4lmhblicy