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Purpose of review To explore how ethical considerations, improved diagnostics and data from clinical trials might see the lowering of some of the barriers blocking a cure for HIV infection over the next 5 years. Recent findings Despite the recent well publicized but eventually disappointing case reports, there remains only one successful HIV cure, the 'Berlin patient'. We will review the data suggesting that more potent agents might achieve in-vivo viral activation and explore the tantalizingdoi:10.1097/qco.0000000000000123 pmid:25485650 fatcat:4vl3lr7jyraz5pisnmeak4zt74