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X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs
2018
Stem Cell Reports
A dramatic difference in global DNA methylation between male and female cells characterizes mouse embryonic stem cells (ESCs), unlike somatic cells. We analyzed DNA methylation changes during reprogramming of male and female somatic cells and in resulting induced pluripotent stem cells (iPSCs). At an intermediate reprogramming stage, somatic and pluripotency enhancers are targeted for partial methylation and demethylation. Demethylation within pluripotency enhancers often occurs at ESC binding
doi:10.1016/j.stemcr.2018.03.019
pmid:29681539
pmcid:PMC5995367
fatcat:wunlgctwxfcxtggnfwapajj6j4