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A noncontact optical detection system is developed for the in vivo identification and localization of high-grade cervical intraepithelial neoplasia ͑CIN 2,3͒. Diagnostic scans of the entire human cervix are performed following acetic acid application employing three integrated optical measurements: laser-induced fluorescence spectroscopy, white light diffuse reflectance spectroscopy, and video imaging. Full cervical scans comprising 499 interrogation locations at 1-mm spatial resolution aredoi:10.1117/1.2208987 pmid:16822059 fatcat:u3d3ufzcobgnngt7wxeu5qgpzy