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Big brain (bib) is a neurogenic gene that when mutated causes defects in cell fate determination during Drosophila neurogenesis through an unknown mechanism. The protein Big Brain (BIB) has sequence identity with the major intrinsic protein family that includes the water-and ion-conducting aquaporin channels. We show here that BIB expressed heterologously in Xenopus oocytes provides a voltage-insensitive, nonselective cation channel function with permeability to K ϩ Ͼ Na ϩ Ͼ Ͼdoi:10.1523/jneurosci.22-07-02530.2002 pmid:11923418 fatcat:2lcayiaey5gldbildyebrmnlpq