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Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production
2014
Molecules
Preserved Fulltext
Four new withanolides named dmetelins A-D (compounds 1-4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Compounds 1, 4 and 5 showed significant
doi:10.3390/molecules19044548
pmid:24731984
fatcat:fdmftaqzzva4zgbzo5bahhbexi