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Differential Role for Host Translation Factors in Host and Viral Protein Synthesis during Human Cytomegalovirus Infection
The host eIF4F translation initiation complex plays a critical role the translation of capped mRNAs. Although human cytomegalovirus (HCMV) infection increases the abundance and activity of the host eIF4F complex, the requirement for eIF4F components in HCMV replication and mRNA translation has not been directly tested. In this study, we found that decreasing the abundance or activity of eIF4F from the start of infection inhibits HCMV replication. However, as infection progresses, viral mRNAdoi:10.17615/xvzw-6v50 fatcat:5c6dga67g5b4xdpaoj7wqc7bsy